An autosomal recessive exocrine gland disorder where organs become clogged with mucus secreted by the exocrine glands.

• A. Cystic Fibrosis
• B. Pancreatitis
• C. Pheochromocytoma
• D. Diabetes Mellitus

Answer: (A)

Cystic fibrosis is described here. It’s an autosomal recessive disorder caused by mutations in the CFTR gene that disrupt chloride transport across epithelial cells. This leads to dehydration and thick, sticky mucus that clogs exocrine glands in multiple organs. In the lungs, the mucus plugs airways and promotes recurrent infections and obstructive symptoms. In the pancreas and other ducts, the thick secretions block drainage, causing pancreatic exocrine insufficiency and malabsorption of fats. The sweat glands also produce unusually salty sweat, which is a classic clue. Because two carrier parents can pass the defective gene, the autosomal recessive inheritance pattern fits the description of a hereditary mucus-clogging condition.

Pancreatitis is an inflammatory condition of the pancreas, which isn’t defined by widespread mucus plugging of exocrine glands. Pheochromocytoma is a tumor of the adrenal medulla causing excess catecholamines, not mucus obstruction. Diabetes mellitus involves insulin production or action and does not describe exocrine gland mucus plugging. In summary, the combination of autosomal recessive inheritance and mucus obstruction of exocrine gland ducts points to cystic fibrosis.